Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury
نویسندگان
چکیده
منابع مشابه
Up-regulation of CatSper genes family by selenium
BACKGROUND CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression. Here, we investigated the effects of selenium (Se) on the expression of CatSper genes and sperm paramet...
متن کاملRegulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.
The calcium channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility. The steroid hormone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2. However, steroid specificity of ABHD2 has not been evaluated. Here, we explored whether steroid hormones to which human spermatozoa are exposed in the male and female genital tract influe...
متن کاملSperm are promiscuous and CatSper is to blame….
A sperm-specific cation channel (CatSper) facilitates the entry of calcium necessary for rapid changes in sperm motility allowing the cell to navigate the hurdles of the female reproductive tract and successfully to locate the egg. Brenker and colleagues show that CatSper is (directly) activated by a diverse range of small organic molecules that are reported to evoke chemotaxis in human spermat...
متن کاملPanax ginseng induces the expression of CatSper genes and sperm hyperactivation
The cation channel of sperm (CatSper) protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression ...
متن کاملMolecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs
BACKGROUND Sperm ion channel proteins (CatSpers) are essential for sperm hyperactivated motility, and then penetration through the zona pellucida. The CatSper class of proteins have well been characterized in the mouse and human. However, such data for pigs are not available. In the present study, we cloned the porcine CatSper 1-4 genes, analysed their spatial expression in various organs and t...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Pharmacology
سال: 2018
ISSN: 1382-6689
DOI: 10.1016/j.etap.2018.03.007